Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome

Xin Huang; Bi Wu; Miaoxin Chen; Ling Hong; Pengcheng Kong; Zhiyun Wei; Xiaoming Teng

doi:doi:10.18632/aging.103602

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Research Paper Volume 12, Issue 15 pp 15414—15435

Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome

Figure 1. Characterization of exosomes isolated from human follicular fluid. (A). Transmission electron micrographs (TEM) of exosomes isolated from follicular fluid. Scale bar, 100 nm. (B) Immunoblots of positive exosomal markers (CD63, CD81) and negative marker (Calnexin) in representative follicular fluid exosomes. (C) The representative nanoparticle tracking analysis (NTA) profile of isolated exosomes.