Research Paper Volume 12, Issue 15 pp 15436—15445

MicroRNA-21-3p accelerates diabetic wound healing in mice by downregulating SPRY1

Figure 5. MiR-21-3p accelerates wound healing in vivo. (A) General view of the wound healing process in the mice that received different treatments (n=10, per group); (B) The closure rate of the wound in the mice that received different treatments; (C) The levels of α-SMA, Col 1, and Col 3 mRNA in the tissues from mice in the different treatment groups were measured by qRT-PCR (D, E) The concentrations of bFGF and VEGF in the tissues from the different treatment groups were determined by ELISA. Data are presented as the mean ± SD from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.