Research Paper Volume 12, Issue 22 pp 22527—22537

Cationic solid lipid nanoparticles loaded by integrin β1 plasmid DNA attenuates IL-1β-induced apoptosis of chondrocyte

Figure 5. Solid lipid nanoparticles-integrin β1 overexpression plasmid (SLNs-pDNA) inhibited cell apoptosis in IL-1β-induced rat chondrocytes. (A) The mitochondrial membrane potential of rat chondrocytes treated with IL-1β (model group), or IL-1β + SLNs-pDNA (SLNs-pDNA group). (B) Cell apoptosis rate in rat chondrocytes treated with IL-1β (model group), or IL-1β + SLNs-pDNA (SLNs-pDNA group) by flow cytometry analysis. (C) The expression of apoptosis-related proteins, including cleaved caspase-3, and cleaved caspase-9 in rat chondrocytes treated with IL-1β (model group), or IL-1β + SLNs-pDNA (SLNs-pDNA group) by western blotting. *P < 0.05.