Research Paper Volume 12, Issue 18 pp 18221—18237

Figure 2. Associations between baseline pulse pressure and measurements of brain aging. Data from linear mixed-effects models adjusted for age, gender, education, APOE Ɛ4 carrier status, vascular risk factors, cognitive diagnosis, as well as intracranial volume. Increased PP level was associated with an accelerated decline in measurements of brain aging. (A–C) Increased PP level was associated with accelerated decline in hippocampal volume, entorhinal volume and episodic memory performance.