Research Paper Volume 12, Issue 17 pp 17380—17392

Figure 2. Anatomical mapping of CRL components in GBM clinical samples. (A) Expression levels of major CRL component genes SKP1, TCEB1/2, BTBD10, DDB1, TCEB1, TCEB2, BTRC, SOCS1, SOCS3, FBXL2/3/5, FBXW7/11, FBXO9, RBX1, RNF7, UBB, and NEDD8, were mapped based on the anatomic features of clinical samples. (B) Expression levels of the cullin genes CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7 were also mapped. The following anatomic structures were identified by H&E staining based on the Ivy GAP dataset: leading edge, infiltrating tumor, cellular tumor, microvascular proliferation and pseudopalisading cells around necrosis. ACTN1 gene expression was used as a reference.