Research Paper Volume 12, Issue 19 pp 19254—19272

S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway

class="figure-viewer-img"

SAC protects chondrocytes from the cytotoxic effects of TBHP. (A) Chemical structure of SAC. (B) CCK-8 assay results show the viability of chondrocytes treated with 0, 12.5, 25, 50, 100, 200 μM SAC for 24 h. (C) CCK-8 assay results show the viability of chondrocytes treated with different concentrations of SAC (0, 12.5, 25, 50, 100, 200μM) for 24 h and 50 μM TBHP for 2h. (D) Representative phase-contrast images show the morphology of THBP-treated chondrocytes with or without SAC. Note: The data are presented as the means ± SD of five independent experiments; *p < 0.05, **p < 0.01, and ***p < 0.001.