S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway

Zhenxuan Shao; Zongyou Pan; Jialiang Lin; Qingqian Zhao; Yuqian Wang; Libin Ni; Shiyi Feng; Naifeng Tian; Yaosen Wu; Liaojun Sun; Weiyang Gao; Yifei Zhou; Xiaolei Zhang; Xiangyang Wang

doi:doi:10.18632/aging.103757

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Research Paper Volume 12, Issue 19 pp 19254—19272

S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway

SAC protects TBHP-treated chondrocytes against apoptosis. (A) Tunel staining assay results show the number of apoptotic (Tunel-positive) chondrocytes treated with or without SAC for 24 h and 50 μM TBHP for 2 h. (B) Representative western blot images and (C) Histogram plots show the levels of cleaved-caspase3, caspase3, BAX and BCL2 proteins in the chondrocytes treated with or without SAC for 24 h and 50 μM TBHP for 2 h. Note: The data are presented as the means ± SD of three independent experiments. *p < 0.05, **p < 0.01, and ***p < 0.001.