Research Paper Volume 12, Issue 15 pp 15656—15669
CTLA-4 immunotherapy exposes differences in immune response along with different tumor progression in colorectal cancer
Figure 4. Immune microenvironment differences accompany the tumor progression changes in the different immune tissues. The percentage of immune cell subpopulations in different immune tissues isolated from both CT26 and Colon26 animal models in Balb/c female mice. (A) Different immune factor expression ratios in TILs. (B) Different immune factor expression ratios in the lymph node isolated from the armpit. (C) Different immune subpopulations expression ratio in the spleen tissue isolated from an immune-competent mouse. (D) Different immune subpopulation expression ratios in peripheral blood isolated from both CT26 and Colone26 animal models.