Research Paper Advance Articles pp 23668—23683

DNMT3B silencing suppresses migration and invasion by epigenetically promoting miR-34a in bladder cancer

Figure 2. Correlation between the level of DNMT3B and the methylation ratio of the miR-34a promoter in bladder cancer tissues. (A) Relative RNA expression of miR-34a in low-DNMT3B-expression and high-DNMT3B-expression bladder cancer tissues. (B) Correlation between the total score of DNMT3B expression and the relative RNA expression of miR-34a in bladder cancer tissues. (C) The methylation ratio of the miR-34a promoter in low-DNMT3B-expression and high-DNMT3B-expression bladder cancer tissues. (D) Correlation between the total score of DNMT3B expression and the methylation ratio of the miR-34a promoter in bladder cancer tissues. (E) Correlation between the relative RNA expression of miR-34a and the methylation ratio of the miR-34a promoter in bladder cancer tissues. DNMT3B, DNA methyltransferase 3B.