Research Paper Volume 12, Issue 19 pp 19375—19398

HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer

Figure 4. HOXC10 expression is regulated by miR-222-3p. (K, L) Rescue experiment with 8910 cells cotransfected with the miR-222-3p mimic, HOXC10 overexpression plasmid, miR negative control or empty vector. P=0.0002, P<0.0001, and P=0.4823; P=0.0017, P=0.0010, and P=0.7193. Scale bars, 200 μm and 100 μm, respectively. (M, N) Rescue experiment with 8910 cells cotransfected with the miR-222-3p inhibitor, siRNA targeting HOXC10, miR negative control or siRNA negative control. P<0.0001, P=0.0001, and P=0.3069; P=0.0003, P=0.0042, and P=0.3539. Scale bars, 200 μm and 100 μm, respectively.