Research Paper Volume 12, Issue 21 pp 21253—21272

Regulation of the regenerative activity of dental pulp stem cells from exfoliated deciduous teeth (SHED) of children by TGF-β1 is associated with ALK5/Smad2, TAK1, p38 and MEK/ERK signaling

Figure 6. Effect of TGF-β1 on the collagen content of cultured SHED. (A) Collagen content of SHED after exposure to TGF-β1 for 5 days as measured by Sircol collagen assay. Results were expressed Mean ± SE. (B) Effect of SB431542 on the TGF-β1-induced increase in collagen content of SHED. (C) Effect of 5z-7oxozeaenol on the TGF-β1-induced increase in collagen content of SHED. (D) Effect of U0126 on the TGF-β1-induced increase in collagen content of SHED. (E) Effect of SB203580 on the TGF-β1-induced increase in collagen content of SHED. *Denotes statistically significant difference when compared to control, #denotes statistically significant difference when compared with TGF-β1 (5 ng/ml)-treated group.