Research Paper Volume 12, Issue 21 pp 21344—21354

Soy isoflavones ameliorate the cognitive dysfunction of Goto-Kakizaki rats by activating the Nrf2-HO-1 signalling pathway

Figure 3. SIF inhibited neuron loss after 4 weeks of treatment. HE staining was performed on the sections of the rat hippocampus. (A–D) Representative hippocampal photomicrographs of the four groups, 4x, scale bar = 50 μm; (E–H) Representative hippocampal photomicrographs of the four groups, 40x, scale bar = 20 μm. The arrows indicate positive signs of hippocampal neurons (shrunken or irregular shape and deeper staining).