Research Paper Volume 12, Issue 21 pp 21404—21422

CPEB3 functions as a tumor suppressor in colorectal cancer via JAK/STAT signaling

Figure 1. CPEB3 is frequently down-regulated in colorectal cancer tissues. (A) CPEB3 expression in colorectal cancer tissues and other tumors, based on previously published microarray data from the Oncomine database (threshold: P < 0.0001; fold change > 2; gene rank < 10%). (B) Analysis of CPEB3 gene expression in colorectal cancer and normal tissues in TCGA database (n = 246 [224 vs. 22]). (C) qPCR analysis of CPEB3 mRNA expression in human colorectal cancer tissues and matched peri-tumoral tissues (n = 84). (D) Representative immunohistochemical staining of CPEB3 in human colorectal cancer tissues (right) and matched peri-tumoral tissues (left). (E) Western blotting analysis of CPEB3 in human colorectal cancer tissues and matched peri-tumoral tissues (n = 12). (F) Patients in the CPEB3 low-expression group tended to exhibit shorter OS than patients in the high-expression group by Kaplan-Meier analysis (47 vs. 62 months; P = 0.035).