Research Paper Volume 12, Issue 23 pp 23698—23726

The ZiBuPiYin recipe regulates proteomic alterations in brain mitochondria-associated ER membranes caused by chronic psychological stress exposure: Implications for cognitive decline in Zucker diabetic fatty rats

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Figure 8. PPI network and KEGG pathway analysis for the differentially expressed MAM proteins in PSD and PDZ rats. Intricate PPI networks among the differential proteins in the PSD:ZDF (A) and PDZ:PSD (B) groups. Balls represent proteins, some of which are increased (red balls), others decreased (green balls). KEGG pathway enrichment analysis for differential proteins in the PSD:ZDF (C) and PDZ:PSD (D) rats. Alzheimer's disease pathway map in PSD:ZDF (E) and PDZ:PSD (F) rats, respectively. Oxidative phosphorylation pathway map in PSD:ZDF (G) and PDZ:PSD (H) rats, respectively. The upregulated and downregulated proteins are labeled in pink and green, respectively.