Accelerated age-related decline in hippocampal neurogenesis in mice with noise-induced hearing loss is associated with hippocampal microglial degeneration

Hong Zhuang; Jing Yang; Zhihui Huang; Haiqing Liu; Xiaobo Li; Hongyu Zhang; Jiadong Wang; Shen Yu; Kefei Liu; Rui Liu; Mingze Bi; Jian Wang; Richard J. Salvi; Bohua Hu; Gaojun Teng; Lijie Liu

doi:doi:10.18632/aging.103898

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Research Paper Volume 12, Issue 19 pp 19493—19519

Accelerated age-related decline in hippocampal neurogenesis in mice with noise-induced hearing loss is associated with hippocampal microglial degeneration

Hippocampal neurogenesis was significantly correlated with dystrophic microglial morphology. (A) Correlation between the average soma area of Iba1⁺ cells in the DG and the density of DCX⁺ cells in the SGZ. (B) Correlation between average total process endpoints per Iba1⁺ cell in the DG and density of DCX+ cells in the SGZ.