Research Paper Volume 12, Issue 19 pp 19546—19562

Comparison of exosomes derived from induced pluripotent stem cells and mesenchymal stem cells as therapeutic nanoparticles for treatment of corneal epithelial defects

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Proposed underlying mechanisms of iPSCs/MSCs-Exos in corneal epithelial defect healing. We propose that both iPSCs-Exos and MSCs-Exos can promote corneal epithelial repair and regeneration by enhancing HCECs proliferation, migration, promoting cell cycle development and attenuating apoptosis. iPSCs-Exos showed stronger effect on HCECs than MSCs-Exos in all aspects.