Research Paper Volume 13, Issue 2 pp 1872—1882

Multiwalled carbon nanotubes co-delivering sorafenib and epidermal growth factor receptor siRNA enhanced tumor-suppressing effect on liver cancer

class="figure-viewer-img"

Figure 5.

MWNT/Sor/siRNA showed better anti-tumor function in liver cancer xenograft mice. (A) The body weights of mice in different groups, including saline solution (control), MWNTs, siRNA, Sor, MWNT/Sor, or MWNT/Sor/siRNA, respectively, every 3 days for 28 days. (B) The tumor volumes of control, MWNTs, siRNA, Sor, MWNT/Sor, or MWNT/Sor/siRNA, respectively, every 3 days for 28 days. (C) The tumor weights of different treated mice on 28 days. (D) The expression of EGFR and Ki67 in tumor tissues of mice with different groups on 28 days by immunohistochemistry. *P < 0.05; **P < 0.01. Definition of the groups: No. 1: control, No. 2: MWNTs, No. 3: siRNA, No.4: Sor, No. 5: MWNT/Sor, No. 6: MWNT/Sor/siRNA.