Research Paper Volume 12, Issue 19 pp 19563—19584

Free Wanderer Powder regulates AMPA receptor homeostasis in chronic restraint stress-induced rat model of depression with liver-depression and spleen-deficiency syndrome

Figure 4. Evaluation of chronic restraint stress induced rat model representing depression with liver-depression and spleen-deficiency syndrome, as well as effects of FWP on behavior changes. For model evaluation experiment: (A) Body weight increase (g). (BD) Number of grid crossing, standing times, and grooming times in open field test. (E) Urinary excretion rate of xylose test (%). (F) Sucrose consumption (mL). For FWP treatment experiments: (G) Body weight increase (g). (HK) Number of grid crossing, median residence time (s), grooming times, and standing times in open field test. (L) CNQX injection sites in amygdaloid nucleus (marked by methylene blue). n=19 or 20 for (AF), and n=13-15 for G-K. *P<0.05, **P<0.01 compared with the normal group; #P<0.05, ##P<0.01compared with the model group; P<0.05, ♦♦P<0.01 compared with the sham-operated group.