Research Paper Volume 12, Issue 21 pp 21469—21480

The protective effects of memantine against inflammation and impairment of endothelial tube formation induced by oxygen-glucose deprivation/reperfusion

Figure 7. Memantine prevented OGD/R-induced reduced angiogenesis in HUVECs. Cells were treated with memantine (10 μM) for 6 h, followed by exposure to oxygen-glucose deprivation (6 h)/reperfusion (24 h) (OGD/R). Microtubule formation was quantified by Matrigel assay (####, P<0.0001 vs. vehicle group; *****, P<0.0001 vs OGD/R group).