Research Paper Volume 12, Issue 19 pp 19585—19596

Glypican-1-targeted and gemcitabine-loaded liposomes enhance tumor-suppressing effect on pancreatic cancer

Figure 4. GPC1-LP (GEM) induced cell apoptosis in PANC-1 cells and SW1990 cells. (A) Cell apoptosis rate of PANC-1 cells treated with PBS (control), LP, GPC1-LP, GEM, LP (GEM) and GPC1-LP (GEM) by flow cytometry analysis. (B) The expression of apoptosis-related proteins (Bcl-2, Bax, cleaved-caspase-3, and cleaved-caspase-9) in PANC-1 cells and SW1990 cells treated with PBS (control), GEM, LP (GEM) and GPC1-LP (GEM) by western blotting. *p<0.05.