Research Paper Volume 12, Issue 21 pp 21559—21581

Single-cell transcriptome analysis demonstrates inter-patient and intra-tumor heterogeneity in primary and metastatic lung adenocarcinoma

Figure 3. Functional enrichment analyses of DEGs between primary LUAD and brain metastases without prior treatment. (A) The volcano plot shows the upregulated and downregulated DEGs between primary LUAD tissues and brain metastases tissues without chemotherapeutic treatment. (BE) The bubble plots show significantly enriched KEGG pathways, biological processes (BP), cellular components (CC), and molecular functions (MF) based on the analysis of the DEGs between primary LUAD tissues and brain metastases tissues without chemotherapeutic treatment. (F) The pie chart and pathway network show the results of functional enrichment analysis of the downregulated genes in primary LUAD tissues and brain metastases tissues without chemotherapeutic treatment. (G) The pie chart and the pathway network show the results of the functional enrichment analysis of upregulated genes in primary LUAD tissues and brain metastases tissues without chemotherapeutic treatment.