Research Paper Volume 12, Issue 21 pp 21559—21581

Single-cell transcriptome analysis demonstrates inter-patient and intra-tumor heterogeneity in primary and metastatic lung adenocarcinoma

Figure 5. Functional enrichment analyses of the DEGs in the tumor cell subgroups of the brain metastasis sample, GSM3516671. (A) UMAP plot shows the different trajectories of the four tumor cell subgroups in GSM3516671. (B) Heatmap shows the differentially expressed genes (DEGs) in the four tumor cell subgroups of the brain metastasis sample, GSM3516671. (CE) Pie graphs show the enrichment analysis for the three tumor cell subgroups of the brain metastasis sample, GSM3516671 (DEGs in the subgroup 4 were not sufficient for enrichment analysis). (F) Gene set variation analysis (GSVA) of the 4 tumor cell subgroups in the brain metastasis sample, GSM3516671.