Research Paper Volume 12, Issue 21 pp 21559—21581

Single-cell transcriptome analysis demonstrates inter-patient and intra-tumor heterogeneity in primary and metastatic lung adenocarcinoma

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Figure 6.

Analysis of upregulated genes in GSM3516671-subgroup 1 cells associated with chemotherapy resistance. (A) Increased expression of chemotherapy resistance-associated genes with pseudotime extension of single cell trajectories. (B) Comparative analysis of the expression of chemotherapy resistance-associated genes in subgroups 1-4 of the GSM3516671 sample. (C) Survival analysis based on the high- or low-expression of these chemotherapy resistance-related genes in the TCGA LUAD dataset (n=510).