Figure 4. The effects of DMC-BH and DMC on tumor growth in orthotopic glioblastoma xenograft models. (A) U87-Luc xenograft tumor-bearing nude mice were treated with 20 mg/kg DMC-BH, 20 mg/kg DMC or isometric saline for 18 days. The growth of orthotopic glioblastoma xenografts was monitored by BLI. (B) The sizes of orthotopic glioblastoma xenografts were measured using an IVIS spectrum image system. (C) The body weight of animals was measured after DMC-BH, DMC or isometric saline treatment.