Research Paper Volume 13, Issue 2 pp 1883—1897

CD36 upregulates DEK transcription and promotes cell migration and invasion via GSK-3β/β-catenin-mediated epithelial-to-mesenchymal transition in gastric cancer

Increased CD36 expression is associated with poor clinicopathological features and clinical outcomes in GC patients. (A) Kaplan-Meier analysis of OS based on CD36 expression in GC patients in TCGA database. (B) Kaplan-Meier analysis of OS based on CD36 expression in GC patients in the GEO database. (C) Analysis of CD36 expression in non-metastatic and metastatic GC samples in TCGA database. *p D) Representative images of CD36 IHC in GC specimens. Top: negative CD36 expression; bottom: positive CD36 expression; left: IHC images, 200×; right: IHC images, 400×. (E) Association between CD36 expression and overall survival in 79 GC patients (p = 0.030).

Figure 1. Increased CD36 expression is associated with poor clinicopathological features and clinical outcomes in GC patients. (A) Kaplan-Meier analysis of OS based on CD36 expression in GC patients in TCGA database. (B) Kaplan-Meier analysis of OS based on CD36 expression in GC patients in the GEO database. (C) Analysis of CD36 expression in non-metastatic and metastatic GC samples in TCGA database. *p < 0.05 vs. non-metastasis group. (D) Representative images of CD36 IHC in GC specimens. Top: negative CD36 expression; bottom: positive CD36 expression; left: IHC images, 200×; right: IHC images, 400×. (E) Association between CD36 expression and overall survival in 79 GC patients (p = 0.030).