Research Paper Volume 13, Issue 2 pp 1883—1897

CD36 upregulates DEK transcription and promotes cell migration and invasion via GSK-3β/β-catenin-mediated epithelial-to-mesenchymal transition in gastric cancer

CD36 upregulates GSK-3β/β-catenin signaling by enhancing DEK expression in GC cells. (A) Western blot analysis of GSK-3β/p-Ser9-GSK-3β and β-catenin/p-β-catenin in SNU-216 cells transfected with NC/siCD36. Data are presented as the mean ± SD.*p  (B) Schematic representation of the proposed mechanism by which CD36 overexpression induces EMT in GC cells.

Figure 6. CD36 upregulates GSK-3β/β-catenin signaling by enhancing DEK expression in GC cells. (A) Western blot analysis of GSK-3β/p-Ser9-GSK-3β and β-catenin/p-β-catenin in SNU-216 cells transfected with NC/siCD36. Data are presented as the mean ± SD.*p < 0.05 vs. NC group. GAPDH was used as endogenous control. (B) Schematic representation of the proposed mechanism by which CD36 overexpression induces EMT in GC cells.