Figure 1. The expression of miR-338-5p decreased in APP/PS1 mice during AD progression. (A) qRT-PCR analysis of miR-338-5p expression in the brains of wild-type (WT) and APP/PS1 mice with increasing age. Data are presented as relative to that of 2-month-old mice. (B, C) ELISA analysis of Aβ 40 (B) and Aβ 42 (C) level in the brains of WT and APP/PS1 mice with increasing age. Data are presented as ng Aβ 40 or Aβ 42 per ml total protein samples. Results are presented as mean ± SD. n = 6 in each group. *P < 0.05; **P < 0.01; ***P<0.001.