Research Paper Volume 12, Issue 20 pp 20728—20742

MicroRNA-338-5p alleviates neuronal apoptosis via directly targeting BCL2L11 in APP/PS1 mice

Figure 2. Lentiviral overexpression of miR-338-5p through intrahippocampal injection improved cognitive dysfunction in APP/PS1 mice. (A) qRT-PCR analysis of miR-338-5p expression in the brain. Data are presented as relative to that of 8-month-old mice infected with lentiviral empty vector. (B) Spatial learning of 8-month-old or 10-month-old APP/PS1 mice was detected as escape latency at different days after training in water maze. (C, D) Spatial memory of 8-month-old or 10-month-old APP/PS1 mice was assessed by probe trials 24 h after the last training session. The number of platform crossing (C), time spent in target quadrant (D) and swimming speed (E) of 8-month-old or 10-month-old APP/PS1 mice were recorded. Results are presented as mean ± SD. n = 6 in each group. *P < 0.05; **P < 0.01; ***P<0.001.