Figure 8. SEMA4C expression negatively correlates with the DNA methylation status of the SEM4AC gene in the CRC patients. (A) Spearman’s correlation analysis shows the relationship between DNA methylation status of the SEMA4C gene and the expression levels of SEMA4C mRNA in the CRC samples. Note: R denotes the Spearman’s correlation coefficient. (B) Boxplots show the methylation levels of the CpG island shore, cg07166409 (left) and cg00605777 (right) in the SEMA4C gene in CRC patients with low- and high-expression of SEMA4C. (C) Kaplan-Meier survival curves show the OS of TCGA-CRC patients with hypomethylation (blue line) and hypermethylation (red line) of the SEMA4C gene in the CpG island shore, cg07166409 (above) and cg00605777 (below).