Research Paper Volume 12, Issue 21 pp 22078—22094

Prognostic risk signature based on the expression of three m6A RNA methylation regulatory genes in kidney renal papillary cell carcinoma

Figure 4. Validation of the prognostic risk signature in the testing cohort and entire cohort. (A) Kaplan-Meier curve analysis shows the overall survival rates of high-risk (n=47) and low-risk (n=47) KIRP patients in the testing cohort. (B) Kaplan-Meier curve analysis shows the overall survival rates of high-risk (n=119) and low-risk (n=118) KIRP patients in the entire TCGA cohort. (C, D) ROC curve analyses of the (C) testing cohort and (D) the entire TCGA-KIRP cohort show the false positive rate vs. true positive rate plots based on the prognostic risk signature. The AUC values for 1-year (blue), 3-year (green), and 5-year (red) survival rates are also shown. (E, F) The risk score distribution, survival status and prognostic risk gene expression in the (E) testing cohort and (F) entire TCGA-KIRP cohort is shown.