Research Paper Volume 12, Issue 22 pp 23114—23128

Intracellular and extracellular S100A9 trigger epithelial-mesenchymal transition and promote the invasive phenotype of pituitary adenoma through activation of AKT1

Figure 5. Upregulation of S100A9 in IPA clinical specimens. Immunohistochemical staining(×400) of S100A9 in non-invasive PA and IPA. The mean optical density was used for statistical quantification of S100A9 in non-invasive PA and IPA. (***P<0.001 vs. non-invasive PA).