Research Paper Advance Articles pp 24033ā€”24056

lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration

Figure 4. (A) Relative expression of DLEU2, miR-181a, SEPP1, SV2A, GOT1 and GFOD1 as detected by qPCR in samples from clinical cohorts. (B) SEPP1 is downregulated in muscle tissues (GTEX cohort; n =7858). An expression map showing SEPP1 protein expression in human tissues. (C) DLEU2 is downregulated in muscle tissues (GTEX cohort; n =7858). An expression map showing DLEU2 protein expression in human tissues. (D) Correlations among DLEU2, miR-181a, SEPP1, SV2A, GOT1 and GFOD1 in muscle tissues (clinic cohort; n = 50). (Eā€“F) Comparison of expression scores of DLEU2 with those of SEPP1 or miR-181a in muscle tissues. The correlations shown are for muscle tissues from clinical cohorts (n=50) and normal muscle tissues from GTEX cohorts (n=396).