Figure 2. Screening of differentially expressed circRNAs. (A) The differential expression of circRNAs in ccRCC tissue samples compared with normal healthy kidney samples. (B) The differential expression of circRNAs in metastatic ccRCC tissue samples compared with local ccRCC tissue samples. (C) 114 circRNAs related to ccRCC progression and metastasis after the intersection. (D) Heatmap for top 5 up-regulated and top 5 down-regulated differentially expressed circRNAs. ccRCC: clear cell renal cell carcinoma.