Research Paper Volume 12, Issue 22 pp 23326—23336

The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression

Figure 4. MiR-497 inhibition reversed the inhibitory effects of DLG1-AS1 knockdown in PTC cells. (A)The expression of miR-497 was assessed in TPC-1 cells transfected with sh-NC, sh-DLG1-AS1, and sh-DLG1-AS1+miR-497 inhibitor (anti-miR-497). (BE) Inhibition of miR-497 partially reversed the inhibitory effects of DLG1-AS1 knockdown on cell proliferation, colony formation, migration, and invasion in TPC-1 cells. All experiments were performed in triplicate, and data are expressed as the mean ± standard deviation (SD) (*P < 0.05, **P < 0.01).