Research Paper Volume 12, Issue 23 pp 24228—24241

The value of a metabolic reprogramming-related gene signature for pancreatic adenocarcinoma prognosis prediction

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Figure 4.

Validation of expression and alteration of the three genes in pancreatic cancer. (AC) The MET, CD36 and ENO3 mRNA expression levels in TCGA pancreatic cancer tumor tissue and matching normal tissue from data on TCGA and GTEx. Data were obtained from the GEPIA (http://gepia.cancer-pku.cn/). (DF) The MET, CD36 and ENO3 mRNA expression levels in GEO32676 and GEO15471 pancreatic cancer tumor tissue compared with non-tumor tissues. (GI) The representative protein expression of the 3 glycolysis and lipid metabolism-based genes in pancreatic cancer tumor tissue. Data were obtained from the human protein atlas (https://www.proteinatlas.org/). (JL) Survival analysis of patients with PAAD in terms of MET, CD36 and ENO3 in TCGA patients. (M) Genetic alterations of the three genes in the ICGC, QCMG, TCGA and UTSW pancreatic cancer datasets. Data were obtained from the cBioportal (https://www.cbioportal.org/).