Research Paper Volume 12, Issue 24 pp 25469—25486

Tumor necrosis factor superfamily 14 is critical for the development of renal fibrosis

Figure 2. Increased TNFSF14 expression in patients with fibrotic nephropathy. (A) The expression of TNFSF14 in human kidney sections from healthy control, CKD patients were detected by immunohistochemistry (upper lane, original magnification×200; lower lane, original magnification×400). (B) The expression of TNFSF14 receptors (HVEM and LTβR) in biopsied human kidney specimens from patients with CKD were detected by immunohistochemistry. (upper lane, original magnification×200; lower lane, original magnification×400). Nontumoral kidney tissue from patients with renal cell carcinoma was used as healthy control. (C) TNFSF14 levels in serum from healthy controls (n = 8) and patients with CKD (n = 16) were measured by ELISA. The data were representative of the results of three independent experiments. Values are represented as mean ± SEM. *P < 0.05.