Research Paper Advance Articles pp 24255—24269

Exploring the mechanism of resistance to sorafenib in two hepatocellular carcinoma cell lines

Figure 5. Potential mechanisms of resistance to sorafenib in hepatocellular carcinoma (HCC). (A) Expression of microRNAs (miRNAs) associated with resistance. (B) Comprehensive landscape of miRNAs and transcription factors (TFs) regulating pathways perturbed in sorafenib-resistant HCC. The border color of nodes reflects the log (fold change) in HepG2 cells; the inside color reflects the log (fold change) in Huh7 cells. (C) Potential mechanisms of resistance to sorafenib.