Research Paper Volume 13, Issue 1 pp 460—476

Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila

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Figure 2. DHM can improve stress tolerance and delay the intestinal dysfunction. (A) Survival curve of fly starvation on the 1.5% agar food, showing DHM improves starvation resistance (p=2.7x10-5, log-rank test). (B) TAG levels of wDah flies that were measured after 14 days of DHM treatment. (C) Oil red O staining of 14 days old fly guts. (D) Drosophila climbing ability from 10 days to 35 days (ns means “No significant difference”, * means p<0.05, **means p<0.01). (E) The percentage of ‘‘Smurf’’ flies. DHM treatment improves intestinal integrity in aged flies. (***p < 0.001, n >90 females for each genotype). (F) The numbers of colony-forming units (CFUs) in intestinal extracts of control and DHM-treated flies (ns means “No significant difference”, * means p<0.05, **means p<0.01; n=10; repeat=3), NR: Nutrient-rich medium, LMRS: Lactobacilli, ACE: Acetobacteria, ENT: Enterobacteria.