Research Paper Volume 13, Issue 1 pp 460—476

Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila

DHM can repress pERK and activate the AOP. (A) Western blots showed the pERK and ERK protein levels in the control and DHM-treated flies. The bar graph illustrated the densitometry of the blots. (B) Western blots showed the AOP protein levels in the control and DHM-treated adult flies. The bar graph illustrated the densitometry of the blots (p=0.0019, n=3). (C) The AOP target genes obp99b, lac, and CG1678 expression levels (relative to actin-5C) in the DHM-treated flies (p=0.0079, p=0.031, p=0.046; n=3).

Figure 4. DHM can repress pERK and activate the AOP. (A) Western blots showed the pERK and ERK protein levels in the control and DHM-treated flies. The bar graph illustrated the densitometry of the blots. (B) Western blots showed the AOP protein levels in the control and DHM-treated adult flies. The bar graph illustrated the densitometry of the blots (p=0.0019, n=3). (C) The AOP target genes obp99b, lac, and CG1678 expression levels (relative to actin-5C) in the DHM-treated flies (p=0.0079, p=0.031, p=0.046; n=3).