Research Paper Volume 13, Issue 1 pp 782—793

Nitidine chloride suppresses NEDD4 expression in lung cancer cells

Downregulation of NEDD4 enhances NC-involved inhibition of cell motility. (A) Cell migration and invasion were evaluated in lung cancer cells after combination treatments. NC: Nitidine chloride; siRNA: NEDD4 siRNA; Both: NEDD4 siRNA plus NC. (B) Quantitative data are shown for motility. **P##p

Figure 6. Downregulation of NEDD4 enhances NC-involved inhibition of cell motility. (A) Cell migration and invasion were evaluated in lung cancer cells after combination treatments. NC: Nitidine chloride; siRNA: NEDD4 siRNA; Both: NEDD4 siRNA plus NC. (B) Quantitative data are shown for motility. **P<0.01, vs the control; ##p<0.01, vs NC only or NEDD4 siRNA transfection only.