Figure 1. Overview of circRNA-seq profiles. (A) The quantity of total circRNAs and circRNAs with differential expression (upregulated and downregulated). (B) Hierarchical clustering heat map of differentially expressed circRNAs in the three groups. (C) CircRNAs with significant differential expression were classified by different genomic loci (exonic, intronic, antisense, intragenic, and intergenic).