Figure 1. Expression of miR-588 in TCGA database and serum of GC patients. (A) Volcano map of the differential expression of miRNAs in gastric cancer. (B) The miRNA-mRNA network; green diamonds are downregulated miRNAs. (C, D) Expression of CEA and CA 19-9 was higher in GC (n = 45) compared to normal samples (n = 37). (E) miR-588 expression was low in serum of GC patients. (F) Receiver operating characteristic (ROC) curves of miR-588, CEA, and CA 19-9. (G) RT-PCR analysis of miR-588 expression relative to control U6+ expression in GES-1, MNK28, and SGC7901 cells.