Research Paper Volume 13, Issue 2 pp 2118—2134

IGF2 improves the developmental competency and meiotic structure of oocytes from aged mice

Reduced serum IGF2 protein levels and reduced Igf2 expressions in oocytes from aged mice. (A) Serum IGF2 concentration in young and aged mice assessed via ELISA. n=3 for each group. (B) qPCR results showing mRNA levels of Igf2 and target genes in GV-stage and MII-stage oocytes from young and aged mice. Student’s t-test (two-tailed). *p

Figure 1. Reduced serum IGF2 protein levels and reduced Igf2 expressions in oocytes from aged mice. (A) Serum IGF2 concentration in young and aged mice assessed via ELISA. n=3 for each group. (B) qPCR results showing mRNA levels of Igf2 and target genes in GV-stage and MII-stage oocytes from young and aged mice. Student’s t-test (two-tailed). *p < 0.05. Error bars indicate the SEM.