Research Paper Volume 13, Issue 2 pp 2118—2134

IGF2 improves the developmental competency and meiotic structure of oocytes from aged mice

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Figure 5. IGF2 improves the mitochondrial ultrastructure of oocytes from aged mice. (A) Representative TEM micrographs of mitochondria from control and IGF2-treated oocytes at 2,500x magnification. Scale bar = 1 μm. Note the normal (Mn) and vacuolated (Mv) mitochondria. (B) Quantification of mitochondria per defined region of interest (ROI) in control and IGF2-treated oocytes. n=9 oocytes for each group. A Student’s t-test (two-tailed). *p < 0.05. Error bars indicate the SEM. (C) Representative TEM micrographs of mitochondria from control and IGF2-treated oocytes at 60,000x magnification. Inner membrane (IM), outer membrane (OM), and intermembrane space (IMS). Scale bar = 200 nm.