Figure 4. MiR-198 was down-expressed in glioma and its overexpression inhibited the progression of TMZ-resistant glioma cells. (A, B) Analysis of the relative expression of miR-198 in glioma tissues, glioma cells (U138 and LN18) and TMZ-resistant glioma cells (U138/TMZ and LN18/TMZ). (C) The viability of U138/TMZ and LN18/TMZ cells transfected with miR-198 mimic was detected by CCK-8 assay. (D) Proliferation of U138/TMZ and LN18/TMZ cells was determined by colony formation assays. (E) Apoptotic rate in U138/TMZ and LN18/ TMZ cells was detected by flow cytometry. (F) The TMZ resistance of U138/TMZ and LN18/TMZ cells was measured by CCK-8 assay. *P < 0.05, **P < 0.01, ***P < 0.001.