Figure 6. MiR-654-3p targeted HDGF directly. (A–C) Prediction of miR-654-3p targets by bioinformatics analysis (miRTarBase; MicroT-CDS; miRDB). (D) High HDGF expression in AML tissues was assessed by TCGA database. (E) Relative HDGF expression in normal tissues was explored by CPTAC database. (F) High HDGF expression was linked to poor OS in AML patients. (G) The correlation among miR-654-3p and HDGF was explored by luciferase reporter assays. (H, I) miR-654-3p mimics decrease the HDGF levels in AML cells at both the mRNA and protein levels. *P<0.05.