Research Paper Advance Articles pp 24057—24080

Age-related DNA methylation changes are sex-specific: a comprehensive assessment

Figure 1. Identification of sex- and age-associated differentially methylated positions (saDMPs). (A) The procedure used to identify saDMPs and snaDMPs. (B) Scheme of the number of sDMPs, aDMPs and saDMPs, divided according to the direction of methylation changes respect to sex (hyper- or hypo-methylated in males compared to females) and age (hyper- or hypo-methylated with increasing age). (C) Scatter plots of a selection of saDMPs: cg01620164 is hypomethylated in males and undergoes age-associated hypomethylation; cg03890691 is hypomethylated in males and undergoes age-associated hypermethylation; cg07128102 is hypermethylated in males and undergoes age-associated hypomethylation; cg04628369 is hypermethylated in males and undergoes age-associated hypermethylation.