Research Paper Volume 13, Issue 2 pp 2310—2329

B3GNT3 overexpression promotes tumor progression and inhibits infiltration of CD8+ T cells in pancreatic cancer

Functional enrichment analysis for B3GNT3. (A) GSEA revealed that T cell receptor signaling pathway related gene set (NES = -1.75, P B3GNT3 expression group. (B) Co-expression analysis for B3GNT3 in the TCGA PC dataset using Pearson correlation coefficients (Pearson correlated coefficient (Cor) > 0.75 or C) Pathway enrichment analysis for B3GNT3. GSEA: gene set enrichment analysis; EMT: epithelial to mesenchymal transition; TCGA, the Cancer Genome Atlas; PC: pancreatic cancer.

Figure 6. Functional enrichment analysis for B3GNT3. (A) GSEA revealed that T cell receptor signaling pathway related gene set (NES = -1.75, P < 0.05, and FDR < 25%) was enriched in the low B3GNT3 expression group. (B) Co-expression analysis for B3GNT3 in the TCGA PC dataset using Pearson correlation coefficients (Pearson correlated coefficient (Cor) > 0.75 or < -0.75, P value < 0.05). (C) Pathway enrichment analysis for B3GNT3. GSEA: gene set enrichment analysis; EMT: epithelial to mesenchymal transition; TCGA, the Cancer Genome Atlas; PC: pancreatic cancer.