Research Paper Volume 13, Issue 2 pp 2310—2329

B3GNT3 overexpression promotes tumor progression and inhibits infiltration of CD8+ T cells in pancreatic cancer

Association between B3GTN3 expression and the immune infiltration within tumor. (A) ESTIMATE algorithm to analyze the correlation between B3GNT3 expression and immune infiltration in PC. (B) CIBERSORT algorithm to analyze the correlation between B3GNT3 expression and immune infiltration in PC. (C) ssGSEA analysis to analyze the correlation between B3GNT3 expression and the immune infiltration in PC. (D) ESTIMATE algorithm and ssGSEA to analyze the correlation between B3GNT3 expression and immune infiltration within tumors in GSE62452 dataset. (E) ssGSEA analysis to analyze the correlation between B3GNT3 expression and immune infiltration within tumors in GSE79668 dataset. TCGA, the Cancer Genome Atlas; PC: pancreatic cancer; ssGSEA: single-sample gene set enrichment analysis; TILs: tumor-infiltrating lymphocytes; Th1 cells: Type-1 T helper cells; Th2/Th1: Type-2 T helper cells/ Type-1 T helper cells.

Figure 8. Association between B3GTN3 expression and the immune infiltration within tumor. (A) ESTIMATE algorithm to analyze the correlation between B3GNT3 expression and immune infiltration in PC. (B) CIBERSORT algorithm to analyze the correlation between B3GNT3 expression and immune infiltration in PC. (C) ssGSEA analysis to analyze the correlation between B3GNT3 expression and the immune infiltration in PC. (D) ESTIMATE algorithm and ssGSEA to analyze the correlation between B3GNT3 expression and immune infiltration within tumors in GSE62452 dataset. (E) ssGSEA analysis to analyze the correlation between B3GNT3 expression and immune infiltration within tumors in GSE79668 dataset. TCGA, the Cancer Genome Atlas; PC: pancreatic cancer; ssGSEA: single-sample gene set enrichment analysis; TILs: tumor-infiltrating lymphocytes; Th1 cells: Type-1 T helper cells; Th2/Th1: Type-2 T helper cells/ Type-1 T helper cells.