Research Paper Volume 13, Issue 2 pp 2348—2364

Upregulation of HOTAIRM1 increases migration and invasion by glioblastoma cells

HOTAIRM1 is upregulated in GBM tissues and cells. (A) HOTAIRM1 was significantly upregulated in GBM samples (n = 163) compared with corresponding normal tissues (n = 207) according to the GEPIA database. (B) Relative HOTAIRM1 expression was analyzed in 5 normal brain tissues and 15 glioma tissues (5 grade II, 5 grade III, and 5 grade IV). (C) Relative expression of HOTAIRM1 in normal brain tissues and different grades of glioma tissues was determined. (D) Representative images of FISH analysis of HOTAIRM1 expression in normal brain tissues and different grades of glioma tissues. Scale bar = 50 μm. (E) Relative expression of HOTAIRM1 in NHAs and 6 GBM cells was determined. *P P

Figure 1. HOTAIRM1 is upregulated in GBM tissues and cells. (A) HOTAIRM1 was significantly upregulated in GBM samples (n = 163) compared with corresponding normal tissues (n = 207) according to the GEPIA database. (B) Relative HOTAIRM1 expression was analyzed in 5 normal brain tissues and 15 glioma tissues (5 grade II, 5 grade III, and 5 grade IV). (C) Relative expression of HOTAIRM1 in normal brain tissues and different grades of glioma tissues was determined. (D) Representative images of FISH analysis of HOTAIRM1 expression in normal brain tissues and different grades of glioma tissues. Scale bar = 50 μm. (E) Relative expression of HOTAIRM1 in NHAs and 6 GBM cells was determined. *P < 0.05, **P < 0.01.